Product Name :ZYG11B polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Protein zyg-11 homolog B: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements . Prefers Nt-Gly but also has the capacity to recognize Nt-Ser, -Ala and -Cys . Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation . In addition, plays a role in the amplification of cGAS to enhance innate immune response. Mechanistically, strengthens the processes of cGAS binding with dsDNA and assembling oligomers and also accelerates and stabili...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ZYG11B protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1730; Protein zyg-11 homolog B
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ZYG11B.
Modification :Unmodification
