Product Name :SLCO4C1 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Solute carrier organic anion transporter family member 4C1: Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney . Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate . Transport is independent of sodium, chloride ion, and ATP . Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter . The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined . Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SLCO4C1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :OATP4C1; OATPX; SLC21A20; Solute carrier organic anion transporter family member 4C1; OATP-H; Organic anion transporter M1; OATP-M1; Solute carrier family 21 member 20
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SLCO4C1.
Modification :Unmodification
