Product Name :PTPRH polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Receptor-type tyrosine-protein phosphatase H: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of PTPRH protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SAP1; Receptor-type tyrosine-protein phosphatase H; R-PTP-H; Stomach cancer-associated protein tyrosine phosphatase 1; SAP-1; Transmembrane-type protein-tyrosine phosphatase type H
Immunogen :A synthetic peptide encompassing a sequence within the center region of human PTPRH.
Modification :Unmodification
