Product Name :ORMDL1 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :ORM1-like protein 1: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels . When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ORMDL1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ORM1-like protein 1; Adoplin-1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ORMDL1.
Modification :Unmodification
