Product Name :ZDHHC21 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates . Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane . This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor . Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Also has a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular cont...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ZDHHC21 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Palmitoyltransferase ZDHHC21; Zinc finger DHHC domain-containing protein 21; DHHC-21
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ZDHHC21.
Modification :Unmodification
