Product Name :ZCCHC6 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Terminal uridylyltransferase 7: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay . Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets . Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms . Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A . In the absence of LIN28A, TUT7 an...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ZCCHC6 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :HS2; KIAA1711; TUT7; Terminal uridylyltransferase 7; TUTase 7; Zinc finger CCHC domain-containing protein 6
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ZCCHC6.
Modification :Unmodification
