Product Name :TMEM8A polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Post-GPI attachment to proteins factor 6: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells . Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane . In contrast to myomaker (TMEM8C), has no fusogenic activity
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TMEM8A protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :TMEM6; TMEM8; Transmembrane protein 8A; Protein M83; Transmembrane protein 6; Transmembrane protein 8
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TMEM8A.
Modification :Unmodification
