Product Name :CCDC66 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Coiled-coil domain-containing protein 66: Microtubule-binding protein required for ciliogenesis . May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites . Required for the assembly of signaling-competent cilia with proper structure and length . Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex . Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation . Essential for cilium elongation, maintaining ciliary length and stability, and inhibiting disassembly (likely by stabilizing the axoneme) (By similarity). Also plays a role in ciliary Hedgehog pathway activation (By similarity). Plays two important roles during cell division . First, is required for mitotic progression via regulation of spindle assembly, organization and orientat...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CCDC66 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Coiled-coil domain-containing protein 66
Immunogen :A synthetic peptide encompassing a sequence within the center region of human CCDC66.
Modification :Unmodification
