Product Name :SLC38A9 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Neutral amino acid transporter 9: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels . Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated . SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids . Acts as an arginine sensor . Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation . How...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SLC38A9 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Putative sodium-coupled neutral amino acid transporter 9; Solute carrier family 38 member 9
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SLC38A9.
Modification :Unmodification
