Product Name :SPSB3 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :SPRY domain-containing SOCS box protein 3: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1 . The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation . Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle . The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SPSB3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C16orf31; SSB3; SPRY domain-containing SOCS box protein 3; SSB-3
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SPSB3.
Modification :Unmodification
