Product Name :DERL3 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Derlin-3: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins . May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of DERL3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C22orf14; DER3; LLN2; Derlin-3; Degradation in endoplasmic reticulum protein 3; DERtrin-3; Der1-like protein 3
Immunogen :A synthetic peptide encompassing a sequence within the center region of human DERL3.
Modification :Unmodification
