Product Name :GPR65 polyclonal antibody
Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)
Background :G protein-coupled receptor 65: Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions . Activated by an optimal pH of 7.4 . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase . GPR65 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity . May also act as a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids . Plays a role in immune response by maintaining lysosome function and regulating T-cell metabolism . Acts as a regulator of inflammation by mediating pH-sensing of extracellular acidification which takes place in inflamed tissues: activation regulates endo-lysosomal function of immune cells and T-cell m...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of GPR65 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :TDAG8; Psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human GPR65.
Modification :Unmodification
