Product Name :LPHN3 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Adhesion G protein-coupled receptor L3: Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors . ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context . Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient . Following G protein-coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity . Specifically mediates the establishment of Schaffer-collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus (By similarity). Localizes to postsynaptic spines in excitatory synapses...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of LPHN3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA0768; LEC3; Latrophilin-3; Calcium-independent alpha-latrotoxin receptor 3; CIRL-3; Lectomedin-3
Immunogen :A synthetic peptide encompassing a sequence within the center region of human LPHN3.
Modification :Unmodification
