Product Name :TNKS2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Poly [ADP-ribose] polymerase tankyrase-2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking . Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation . Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination . Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length . Stimulates 26S proteasome activity
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TNKS2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :PARP5B; TANK2; TNKL; Tankyrase-2; TANK2; ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-like protein; Tankyrase-related protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TNKS2.
Modification :Unmodification
