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PARP14 polyclonal antibody

货号: BS33233

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS33233

Product Name :PARP14 polyclonal antibody

Swiss-Prot :Q460N5

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Protein mono-ADP-ribosyltransferase PARP14: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins . In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation . Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation . However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' . Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription . In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation . Mono-ADP-ribosylates PARP9

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PARP14 protein

BiowMW :~203 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BAL2; KIAA1268; Poly [ADP-ribose] polymerase 14; PARP-14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2

Immunogen :A synthetic peptide encompassing a sequence within the center region of human PARP14.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Filamin B expression in Hela (A) whole cell lysates.