Product Name :PARP11 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Protein mono-ADP-ribosyltransferase PARP11: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins . Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway . Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity . Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of PARP11 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C12orf6; Poly [ADP-ribose] polymerase 11; PARP-11; ADP-ribosyltransferase diphtheria toxin-like 11; ARTD11
Immunogen :A synthetic peptide encompassing a sequence within the center region of human PARP11.
Modification :Unmodification
