Product Name :NDNL2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Non-structural maintenance of chromosomes element 3 homolog: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination . The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex . May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of NDNL2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :HCA4; MAGEG1; Melanoma-associated antigen G1; Hepatocellular carcinoma-associated protein 4; MAGE-G1 antigen; Necdin-like protein 2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human NDNL2.
Modification :Unmodification
