Product Name :USP49 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Ubiquitin carboxyl-terminal hydrolase 49: Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing . Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity . Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1 . Also regulates the mitotic spindle checkpoint and prevents aneuploidy . Negatively regulates cellular antiviral responses via deconjugating 'Lys-63'-linked ubiquitination of STING1 . Significantly enhances the anti-HIV-1 activity of APOBEC3G. Mechanistically, stabilizes APOBEC3G by coun...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of USP49 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Ubiquitin carboxyl-terminal hydrolase 49; Deubiquitinating enzyme 49; Ubiquitin thioesterase 49; Ubiquitin-specific-processing protease 49
Immunogen :A synthetic peptide encompassing a sequence within the center region of human USP49.
Modification :Unmodification
