Product Name :RAD51AP1 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :RAD51-associated protein 1: Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination . Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 . Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation . Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair . WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 . Also involved in meiosis by promoting DMC1-media...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of RAD51AP1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :PIR51; RAD51-associated protein 1; RAD51-interacting protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human RAD51AP1.
Modification :Unmodification
