Product Name :RNF167 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway . Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 . Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex . Also involved in protein trafficking and localization . Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 . Does not catalyze ubiquitination of GluA1/GRIA1 . Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 . Regulates lysosome positioning by catalyzing ubiquitination and degradation o...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of RNF167 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :E3 ubiquitin-protein ligase RNF167; RING finger protein 167; RING105
Immunogen :A synthetic peptide encompassing a sequence within the center region of human RNF167.
Modification :Unmodification
