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MARCH7 polyclonal antibody

货号: BS32964

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32964

Product Name :MARCH7 polyclonal antibody

Swiss-Prot :Q9H992

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates . May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis . Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 . Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its ubiquitination and subsequent degradation

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of MARCH7 protein

BiowMW :~78.1 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AXOT; RNF177; E3 ubiquitin-protein ligase MARCH7; Axotrophin; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; MARCH-VII; RING finger protein 177

Immunogen :A synthetic peptide encompassing a sequence within the center region of human MARCH7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of EGR2 expression in HEK293T (A), PC3 (B), mouse liver (C), mouse kidney (D), rat liver (E) whole cell lysates.