Product Name :APOBEC3H polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :DNA dC->dU-editing enzyme APOBEC-3H: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms . The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1 . After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA . The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells . Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-strand...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of APOBEC3H protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DNA dC->dU-editing enzyme APOBEC-3H; APOBEC-related protein 10; ARP-10; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; A3H
Immunogen :A synthetic peptide encompassing a sequence within the center region of human APOBEC3H.
Modification :Unmodification
