Product Name :ITFG2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :KICSTOR complex protein ITFG2: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ITFG2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Integrin-alpha FG-GAP repeat-containing protein 2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ITFG2.
Modification :Unmodification
