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RSPO2 polyclonal antibody

货号: BS32767

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32767

Product Name :RSPO2 polyclonal antibody

Swiss-Prot :Q6UXX9

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :R-spondin-2: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway . During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RSPO2 protein.

BiowMW :~28.3 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :R-spondin-2; Roof plate-specific spondin-2; hRspo2

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human RSPO2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of EOMES expression in BV2 (A), C6 (B), A549 (C), Jurkat (D) whole cell lysates.

免疫沉淀（IP）