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FAN1 polyclonal antibody

货号: BS32766

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32766

Product Name :FAN1 polyclonal antibody

Swiss-Prot :Q9Y2M0

Host :Rabbit

Reactivity :Human

Applications :WB, FC

Application_all :WB (1/500 - 1/1000), FC (1/10 - 1/50)

Background :Fanconi-associated nuclease 1: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates . Not involved in DNA double-strand breaks resection . Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL . Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap . Also has endonuclease activity toward 5'-flaps

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FAN1 protein.

BiowMW :~114 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA1018; MTMR15; Fanconi-associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Myotubularin-related protein 15

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human FAN1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD116 expression in rat lung (A) whole cell lysates.

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