Product Name :CMPK2 polyclonal antibody
Applications :WB, IHC, FC
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)
Background :UMP-CMP kinase 2, mitochondrial: Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways . Restricts the replication of multiple viruses including flaviviruses or coronaviruses . Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities . Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity . Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonuc...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CMPK2 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :UMP-CMP kinase 2, mitochondrial; Nucleoside-diphosphate kinase
Immunogen :A synthetic peptide encompassing a sequence within the Central region of human CMPK2.
Modification :Unmodification
