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NPRL3 polyclonal antibody

货号: BS32626

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32626

Product Name :NPRL3 polyclonal antibody

Swiss-Prot :Q12980

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :GATOR1 complex protein NPRL3: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway . In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling . In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of NPRL3 protein.

BiowMW :~63.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C16orf35; CGTHBA; MARE; Nitrogen permease regulator 3-like protein; -14 gene protein; Alpha-globin regulatory element-containing gene protein; Protein CGTHBA

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human NPRL3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ECE2 expression in HepG2 (A) whole cell lysates.