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DDX42 polyclonal antibody

货号: BS32624

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32624

Product Name :DDX42 polyclonal antibody

Swiss-Prot :Q86XP3

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures . Unwinding is promoted in the presence of single-strand binding proteins . Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein . ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands . Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP . Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apop...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of DDX42 protein.

BiowMW :~103 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ATP-dependent RNA helicase DDX42; DEAD box protein 42; RNA helicase-like protein; RHELP; RNA helicase-related protein; RNAHP; SF3b DEAD box protein; Splicing factor 3B-associated 125 kDa protein; SF3b125

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human DDX42.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of IL-1 beta expression in 293 cells transfected with IL1B (A) whole cell lysates.