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L3MBTL1 polyclonal antibody

货号: BS32613

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32613

Product Name :L3MBTL1 polyclonal antibody

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Lethal(3)malignant brain tumor-like protein 1: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of L3MBTL1 protein.

BiowMW :~91.8 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0681; L3MBT; L3MBTL; Lethal(3)malignant brain tumor-like protein 1; H-l(3)mbt; H-l(3)mbt protein; L(3)mbt-like; L(3)mbt protein homolog; L3MBTL1

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human L3MBTL1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of cTnI (Phospho-S23/S24) expression in rat heart (A), H9C2 (B), A549 (C), HEK293T (D), mouse testis (E) whole cell lysates.