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ABL2 polyclonal antibody

货号: BS32572

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32572

Product Name :ABL2 polyclonal antibody

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Tyrosine-protein kinase ABL2: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL or DOK1. Required for adhesion-dependent phosphorylation of ARHGAP35 which promotes its association with RASA1, resulting in recruitment of ARHGAP35 t...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ABL2 protein.

BiowMW :~128 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human ABL2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ELK1 (Phospho-T417) expression in MCF7 (A), SP20 (B), PC12 (C) whole cell lysates.