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FBXO45 polyclonal antibody

货号: BS32562

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32562

Product Name :FBXO45 polyclonal antibody

Swiss-Prot :P0C2W1

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :F-box/SPRY domain-containing protein 1: Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 . Functions in substrate recognition but also plays an important role in assembly of the complex . Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome . Also acts by ubiquitinating FBXW7 duri...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FBXO45 protein.

BiowMW :~30.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FBX45; F-box/SPRY domain-containing protein 1; F-box only protein 45; hFbxo45

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human FBXO45.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of HGS expression in Hela (A) whole cell lysates.

免疫沉淀（IP）