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DNAJC6 polyclonal antibody

货号: BS32558

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32558

Product Name :DNAJC6 polyclonal antibody

Swiss-Prot :O75061

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Auxilin: May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking . Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociat...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of DNAJC6 protein.

BiowMW :~100.0 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0473; Putative tyrosine-protein phosphatase auxilin; DnaJ homolog subfamily C member 6

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human DNAJC6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Amphiphysin 2 expression in C2C12 (A), A431 (B), HEK293 (C), MCF7 (D) whole cell lysates.

免疫沉淀（IP）