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GSPT2 polyclonal antibody

货号: BS32529

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32529

Product Name :GSPT2 polyclonal antibody

Swiss-Prot :Q8IYD1

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Eukaryotic peptide chain release factor GTP-binding subunit ERF3B: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA . GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site . GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GSPT2 protein.

BiowMW :~68.9 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ERF3B; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b; G1 to S phase transition protein 2 homolog

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human GSPT2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Apolipoprotein E expression in HEK293T (A), Hela (B), mouse liver (C), mouse kidney (D), rat liver (E), rat kidney (F) whole cell lysates.