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DTX1 polyclonal antibody

货号: BS32485

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32485

Product Name :DTX1 polyclonal antibody

Swiss-Prot :Q86Y01

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :E3 ubiquitin-protein ligase that mediates ubiquitination and proteasomal degradation of MEKK1, thereby modulating signaling pathways involved in cell fate determination (By similarity). Regulates the Notch signaling pathway, acting predominantly as a positive regulator but functioning as a context-dependent negative regulator in specific developmental or cellular settings. Mediates the antineural activity of Notch signaling, likely by inhibiting transcriptional activation mediated by MATCH1. Negatively regulates Notch signaling by controlling the activity of PIP4K2C, a lipid kinase that promotes recycling of Notch receptors from RAB4A-positive endosomes to the cell surface . Participates in several developmental and immune processes, including neurogenesis, lymphogenesis, and myogenesis. Influences lymphocyte differentiation by promoting B-cell development at the expense of T-cell dev...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of DTX1 protein.

BiowMW :~67.4 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase DTX1; Protein deltex-1; Deltex1; hDTX1

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human DTX1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD25 expression in Hela (A), DLD (B), A2780 (C) whole cell lysates.

免疫沉淀（IP）