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MLK1 polyclonal antibody

货号: BS32462

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32462

Product Name :MLK1 polyclonal antibody

Swiss-Prot :P80192

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Mitogen-activated protein kinase kinase kinase 9: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of MLK1 protein.

BiowMW :~122 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human MLK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of AMPK beta 2 expression in 293T (A), HepG2 (B), mouse heart (C), rat heart (D) whole cell lysates.

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