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HIPK3 polyclonal antibody

货号: BS32455

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32455

Product Name :HIPK3 polyclonal antibody

Swiss-Prot :Q9H422

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Homeodomain-interacting protein kinase 3: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of HIPK3 protein.

BiowMW :~134 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DYRK6; FIST3; PKY; Homeodomain-interacting protein kinase 3; Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; Homolog of protein kinase YAK1

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human HIPK3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of TAU (Phospho-S721/404) expression in mouse brain (A) whole cell lysates.