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RIOK1 polyclonal antibody

货号: BS32445

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32445

Product Name :RIOK1 polyclonal antibody

Swiss-Prot :Q9BRS2

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Serine/threonine-protein kinase RIO1: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor . The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RIOK1 protein.

BiowMW :~65.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine/threonine-protein kinase RIO1; RIO kinase 1

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human RIOK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of HOXC6 expression in A2780 (A), HEK293T (B), PC12 (C), 3T3L1 (D), PC3 (E) whole cell lysates.

Immunohistochemical analysis of HOXC6 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.