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AMER1 polyclonal antibody

货号: BS32425

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32425

Product Name :AMER1 polyclonal antibody

Swiss-Prot :Q5JTC6

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :APC membrane recruitment protein 1: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of AMER1 protein.

BiowMW :~124 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FAM123B; WTX; APC membrane recruitment protein 1; Amer1; Protein FAM123B; Wilms tumor gene on the X chromosome protein

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human AMER1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of B3GALT3 expression in SKOV3 (A) whole cell lysates.

免疫沉淀（IP）