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PARP16 polyclonal antibody

货号: BS32423

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32423

Product Name :PARP16 polyclonal antibody

Swiss-Prot :Q8N5Y8

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :Protein mono-ADP-ribosyltransferase PARP16: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes . Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading . Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 . Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors . May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor . May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PARP16 protein.

BiowMW :~36.4 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C15orf30; Mono [ADP-ribose] polymerase PARP16; ADP-ribosyltransferase diphtheria toxin-like 15; ARTD15; Poly [ADP-ribose] polymerase 16; PARP-16

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human PARP16.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of TDT expression in Jurkat (A) whole cell lysates.

Immunohistochemical analysis of TDT staining in human thymus formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.