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MAGEL2 polyclonal antibody

货号: BS32421

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32421

Product Name :MAGEL2 polyclonal antibody

Swiss-Prot :Q9UJ55

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :MAGE-like protein 2: Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly . Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of MAGEL2 protein.

BiowMW :~133 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NDNL1; MAGE-like protein 2; Necdin-like protein 1; Protein nM15

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human MAGEL2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Pyruvate Kinase expression in A549 (A), Hela (B), MCF7 (C), mouse liver (D), mouse kidney (E) whole cell lysates.

免疫沉淀（IP）