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KIAA0226L polyclonal antibody

货号: BS32413

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32413

Product Name :KIAA0226L polyclonal antibody

Swiss-Prot :Q9H714

Host :Rabbit

Reactivity :Human

Applications :WB, FC

Application_all :WB (1/500 - 1/1000), FC (1/10 - 1/50)

Background :Protein associated with UVRAG as autophagy enhancer: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy . Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex . Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes . Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) . In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of KIAA0226L protein.

BiowMW :~73.5 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C13orf18; Uncharacterized protein KIAA0226-like

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human KIAA0226L.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of RAR beta expression in SKOVCAR3 (A), MCF7 (B), C6 (C), CT26 (D) whole cell lysates.

Immunohistochemical analysis of RAR beta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.