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TRIM50 polyclonal antibody

货号: BS32394

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32394

Product Name :TRIM50 polyclonal antibody

Swiss-Prot :Q86XT4

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 . In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction . Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of TRIM50 protein.

BiowMW :~54.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TRIM50A; E3 ubiquitin-protein ligase TRIM50; Tripartite motif-containing protein 50

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human TRIM50.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of EPO expression in CEM (A) whole cell lysates.

免疫沉淀（IP）