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CPEB4 polyclonal antibody

货号: BS32390

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32390

Product Name :CPEB4 polyclonal antibody

Swiss-Prot :Q17RY0

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Cytoplasmic polyadenylation element-binding protein 4: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR . RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism . Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation . Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT . Stimulates proliferation of melanocytes . In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CPEB4 protein.

BiowMW :~80.2 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA1673; Cytoplasmic polyadenylation element-binding protein 4; CPE-BP4; CPE-binding protein 4; hCPEB-4

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human CPEB4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD16 expression in mouse liver (A), mouse spleen (B) whole cell lysates.

免疫沉淀（IP）