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XAF1 polyclonal antibody

货号: BS32297

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

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No. :BS32297

Product Name :XAF1 polyclonal antibody

Swiss-Prot :Q6GPH4

Host :Rabbit

Reactivity :Human

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)

Background :XIAP-associated factor 1: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor sup...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of XAF1 protein.

BiowMW :~34.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BIRC4BP; XIAPAF1; XIAP-associated factor 1; BIRC4-binding protein

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human XAF1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MTMR5 expression in Raji (A), Jurkat (B), rat brain (C) whole cell lysates.

免疫沉淀（IP）