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FBXL17 polyclonal antibody

货号: BS32292

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS32292

Product Name :FBXL17 polyclonal antibody

Swiss-Prot :Q9UF56

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/30)

Background :F-box/LRR-repeat protein 17: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) . FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome . The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 . The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degrada...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FBXL17 protein.

BiowMW :~75.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FBL17; FBX13; FBXO13; F-box/LRR-repeat protein 17; F-box and leucine-rich repeat protein 17; F-box only protein 13

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human FBXL17.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD99 expression in mouse testis (A) whole cell lysates.

免疫沉淀（IP）