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FCHSD2 polyclonal antibody

货号: BS32234

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS32234

Product Name :FCHSD2 polyclonal antibody

Swiss-Prot :O94868

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :F-BAR and double SH3 domains protein 2: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor . Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling . Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits . Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate . When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerization in the absence of membranes

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FCHSD2 protein.

BiowMW :~84.3 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0769; SH3MD3; FCH and double SH3 domains protein 2; Carom; SH3 multiple domains protein 3

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human FCHSD2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CDK2AP1 expression in HEK293T (A), HEK293T overexpression (B), HEK293T mutant (C), HEK293T knockout (D) whole cell lysates.

免疫沉淀（IP）