Product Name :LIN7B polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Protein lin-7 homolog B: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of LIN7B protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :MALS2; VELI2; Protein lin-7 homolog B; Lin-7B; hLin7B; Mammalian lin-seven protein 2; MALS-2; Vertebrate lin-7 homolog 2; Veli-2; hVeli2
Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human LIN7B.
Modification :Unmodification
