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MBD6 polyclonal antibody

货号: BS32129

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32129

Product Name :MBD6 polyclonal antibody

Swiss-Prot :Q96DN6

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Methyl-CpG-binding domain protein 6: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) . Important for stability of PR-DUB components and stimulating its ubiquitinase activity . As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 . MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways . Heterochromatin recruitment is not mediated by DNA methylation . The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of MBD6 protein.

BiowMW :~101 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA1887; Methyl-CpG-binding domain protein 6; Methyl-CpG-binding protein MBD6

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human MBD6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Trypsin 1 expression in Panc1 (A), HCT116 (B) whole cell lysates.

免疫沉淀（IP）