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TRPC4AP polyclonal antibody

货号: BS32110

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32110

Product Name :TRPC4AP polyclonal antibody

Swiss-Prot :Q8TEL6

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Short transient receptor potential channel 4-associated protein: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control . The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway . The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation . Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Al...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of TRPC4AP protein.

BiowMW :~90.9 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C20orf188; TRRP4AP; Short transient receptor potential channel 4-associated protein; Trp4-associated protein; Trpc4-associated protein; Protein TAP1; TNF-receptor ubiquitous scaffolding/signaling protein; Protein TRUSS

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human TRPC4AP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Cytokeratin 18 expression in HEK293T (A), Hela (B), mouse kidney (C), mouse lung (D), rat kidney (E) whole cell lysates.