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RAB40C polyclonal antibody

货号: BS32099

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32099

Product Name :RAB40C polyclonal antibody

Swiss-Prot :Q96S21

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Ras-related protein Rab-40C: RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration . Also negatively regulate lipid droplets accumulation in a GTP-dependent manner

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RAB40C protein.

BiowMW :~31.3 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RARL; RASL8C; Ras-related protein Rab-40C; Rar-like protein; Ras-like protein family member 8C; SOCS box-containing protein RAR3

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human RAB40C.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of 5-HT1A expression in HEK293T (A), LO2 (B), PC12 (C) whole cell lysates.

免疫沉淀（IP）